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KMID : 0370219970410040480
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Yakhak Hoeji
1997 Volume.41 No. 4 p.480 ~ p.483
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Synthesis of p- ( Acetylamino ) phenylacetic acid As an Antirheumatic Agent
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최홍대/Choi HD
손병화/Son BH
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Abstract
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The efficient synthesis of p-(acetylamino)phenylacetic acid(7), a antirheumatic agent, is reported. Methyl phenylacetate(3) was prepared from Friedel- Crafts reaction of benzene with methyl alpha-chloro-alpha-(methylthio)acetate(1) followed by reductive desulfurization with zinc dust in acetic acid. Compound(7) was obtained from 3 by a sequence of nitration, reduction, N-acylation, and hydrolysis.
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